Enzymes involved in fatty acid metabolism

• Acetyl-CoA Carboxylase (ACC)


• Propionyl-CoA Carboxylase (PCC)


• Methylcrotonyl-CoA Carboxylase (MCC)


• Pyruvate Carboxylase (PC)


• Carnitine Acyltransferase


• AMP-activated Protein Kinase (AMPK)


• Malic Enzyme

Proteins involved in pre-mRNA processing or Pol II termination

• pre-mRNA 3'-end Processing


• 5'->3' exoribonucleases (XRNs)


• Discovery of an mRNA 5'-end capping quality control mechanism

Enzymes involved in NAD+ metabolism

Crystallography Method/Software Development

Toll/Interleukin-1 Receptor (TIR) Domain

BEACH Domain

HCMV Protease

p38 MAP Kinase

SH2 Domain

HIV-2 Protease

Human Renin

Sindbis Virus Capsid Protein

Human ras p21